Bio

Sofosbuvir and Velpatasvir (Figure 1) and (Figure 2) is a pangenotypic NS5A-NS5B inhibitor single-pill combination regimen that has potent activity against hepatitis C virus (HCV) genotypes 1, 2, 3, 4, 5, and 6. It provides a much-needed option for patients with HCV genotype 3 infection, including those with compensated cirrhosis who lack the Y93H resistance associated variant. Sofosbuvir-velpatasvir can, in contrast to HCV protease-inhibitor-containing regimens, be used safely in persons with decompensated cirrhosis. Levels of sofosbuvir-velpatasvir can be significantly reduced with concurrent use of acid-reducing agents, particularly proton-pump inhibitors.https://www.heptopic.com/